糖基转移酶的概述 葡糖基转移酶gtfs结构特点

糖基转移酶的概述 Recent advances in antibiotic glycosyltransferases ABSTRACT Glycoside antibiotics，a category of compounds widely used clinically for anti？bacterial and anti？cancer，are catalyzed by antibiotic glycosyltransferases(Gtfs)in vivo.The sugar moieties are transferred to the corresponding aglycon by Gtfs，often work at very late stages of biosynthesis of antibiotics.The position，type and number of sugar moieties incorporated to the antibiotics have great impact on its bioactivity.This article provides an overview of the categories，functions，characteristics of Gtfs，their applications in combinatorial biosynthesis，and the prospects for research.KEY WORDS Antibiotic glycosyltransferase；Glycoside antibiotics；Glycosylation抗生素糖苷在临床上主要用于抗菌和抗肿瘤，在抗生素生物合成基因簇中已经发现了很多编码糖基转移酶的基因[1]，但人们对抗生素糖基转移酶(antibiotic glycosyltransferases，Gtfs)的特异性和催化机制了解不多。糖基与不同配基的结合能大大增加天然产物的结构多样性，在功能上，这些糖组分通常。

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